Can I buy a residential property and rent out rooms as office space?

Or does the house have to be zoned as commercial?

The house would have to be zoned as commercial and in most areas, a variance would not be granted unless you are EXTREMELY close to commercial property (as in the same block).

Remember that renting as office space isn't that simple...because it will have to meet ADA guidelines.

most of the answers are incorrect. if there is any sort of buisness within a certain area u can get a residential/commercial zoning Report It

The property would need to be rezoned to an office-institutional or a mixed use category allowing office use, NOT commercial. Also, you cannot get a variance to allow an office use in a residentially zoned area. There is no such thing as a use variance. Report It

The house has to be zoned commercial for you to do that. There are homes, usually close to downtown that are zoned for commercial use.

You could if the property was zoned commercial.

Yes - it all depends on zoning. Contact your local town clerk to lookup the zoning of your property.

Heck no. You want to wreck the neighborhood for your personal financial gain. That is bad karma.